清末民初,佛山武学宗师黄飞鸿因噩梦预感女记者莫十三遇险,携弟子前(qián )往(wǎng )古(gǔ )云(yún )村(cūn )寻(xún )人(rén )。村(cūn )中(zhōng )蜈(wú )蚣(gōng )教借蛊术胁迫村民献祭孩童,莫十三探查真相时被擒,身中噬魂蛊。黄飞鸿闯祭坛救人,因不忍伤及被蛊惑的村民反中蛊毒,幸得卧底蜈蚣教的鬼脚(jiǎo )七(qī )暗(àn )中(zhōng )相(xiàng )助(zhù )。众(zhòng )人(rén )合力破除水源蛊毒,救治村民,鬼脚七伤愈拜师。巫师自焚后,线索指向广州东瀛会馆。黄飞鸿潜入会馆救出被掳孩(hái )童(tóng ),对(duì )决(jué )主(zhǔ )事(shì )服(fú )部(bù )一(yī )郎(láng ),得知幕后黑手为西洋吸血鬼麦克罗。麦克罗散播疫毒祸乱羊城,以莫十三性命相要挟。黄飞鸿于绝境中融合腿法,悟出佛山无影脚,击杀麦克罗。蛊毒(dú )尽(jìn )解(jiě ),百(bǎi )姓(xìng )恢(huī )复(fù )神(shén )智,广州重归太平,宝芝林重回烟火日常。